Bone Abstracts

Vitamin D and its metabolites are bound to vitamin D binding protein (DBP) in the circulation. Only a small proportion is in unbound, free form. According to the ‘free-hormone-hypothesis’ only the free form is biologically active. DBP is a polymorphic protein and different variants of the protein differ in their ability to bind vitamin D. This may have an impact on the amount of free and bioavailable (free+albumin-bound) 25-hydroxyvitamin D (25(OH)D) in the circulati...

Phosphorus intake in western countries is high due to abundant consumption of animal protein and also because of the expanding use of highly absorbable food additive phosphate (FAP) salts in food processing. P is essential for hydroxyapatite in bone, but short-term studies have shown that high P, especially FAP, intake has acute negative effects on bone metabolism. In this study, we investigated the associations between dietary P intake and bone turnover markers by using a cro...